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Drug missiles: Dynamic Medicine Route Simulation:

When people are ill, they take tablets, capsules or get injections. What happens to medicines once they are in our bodies? How do they find the right place? Are they chasing virus or bacteria like the shark-fish game?

Although medicines take different routes and they fight different illness like pain, infection or cancer, they normally will move into the blood stream and then organs and tissues. I would like to simplify this process and focus on a particular stage. Assume the drug molecules are at the gate of the infected organ. The project will first simulate how these molecules find their targets now. The next step will imagine how they can be guided to their targets in the future.

Basic Elements included here are:

Medicine_Particles:

  • small(its proportion to cells as 1 to 10^3);
  • very large amount(10^4)
  • random move from one side towards the other side(like data); disappear at the end(they are consumed)
  • meet empty space: keep move
  • meet other particles:form a group and move together;
  • meet cells:
    • good :move on(enter by zero probability,pe=0%)
    • tumor:enter target by a probability(like pe=10%); lost original velocity(v);stay there;
  • after kill a tumor, change to other inactive particles and move on the the end-side;

Particle_groups:

  • same as single particles only move slower
  • if the group size>= x(like 5), group will stop(v=0) and swallowed by leukocyte

Cells:

  • volume are large, occupy many spaces(30*30, about one tile??)
  • stay still, do not move
  • grow, divide when volume is big enough(like vl>=1500)
  • have membrane
    • Good_cells: grows after some time(like t1=10^3)
    • Tumor_cells:grows faster than good cells(like t2⇐500);
      • by a probability(like pt=10%) turns good cells into tumor by a time(like t3>= 200)
      • killed by particles(like n>=10)

Blood_Streams:

  • Particles will move along blood streams.
  • Empty spaces must be left between Cells.
playground/playground.1410929766.txt.gz · Last modified: 2014/09/17 04:56 by xychen