User Tools

Site Tools


playground:playground

This is an old revision of the document!


Drug missiles: Dynamic Medicine Route Simulation:

When people are ill, they take tablets, capsules or get injections. What happens to medicines once they are in our bodies? How do they find the right place? Are they chasing virus or bacteria like the shark-fish game?

Although medicines take different routes and they fight different illness like pain, infection or cancer, they normally will move into the blood stream and then organs and tissues. I would like to simplify this process and focus on a particular stage. Assume the drug molecules are at the gate of the infected organ. The project will first simulate how these molecules find their targets now. The next step will imagine how they can be guided to their targets in the future.

Basic Elements included

  • Medicine_Particles:

they are small particles(its proportion to cells as 1 to 10^3);

they are in very large amount(10^4)
they move:
	when meet empty space	
		move from one side towards the other side(like MFM data); fast(like v=100);disappear at the end 
		as a whole they move under a fast trend(like v=100), each individuals has its random movements
	when meet other particles
		tend to form a group and move together; they will be swallowed by leukocyte if the group size>= x(like 5) 
	when meet cells:
		meet good cells:move on(enter by zero probability,pe=0%)
		meet tumor cells:enter this target by a probability(like pe=10%); 
				 lost original trend(v);
				 keep random move;
				 when enough particles enter(like n>=10), kill tumor cell
				 after kill the tumor, change to some inactive status; released from tumor area,gain trand(v) again	
  • Particle_groups:

same as single particles only move slower

large group will stop(v=0) and swallowed by leukocyte 
  • Cells:

they are large, occupy many spaces

they will split or divide when volume is big enough(like vl>=1500)
they are still, do not move
Good_cells: 
	grows after some time(like t1=10^3)
Tumor_cells:
	grows faster than good cells(like t2<=500)
	by a probability(like pt=10%) turns good cells into tumor by a time(like t3>= 200)
  • Blood_Streams:

These are the passage particles move along. We can leave empty spaces function like this.

playground/playground.1410671775.txt.gz · Last modified: 2014/09/14 05:16 by xychen