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people:xinyu_chen:drugmissile

Drug attractors: Dynamic Medicine Route Simulation:

When people are ill, they take tablets, capsules or get injections. What happens to medicines once they are in our bodies? How do they find the right place? Are they chasing virus or bacteria like the shark-fish game?

Although medicines take different routes and they fight different illness like pain, infection or cancer, they normally will move into the blood stream and then organs and tissues. I would like to simplify this process and focus on a particular stage. Assume the drug particles have already entered the ill organ. The project will simulate the growth and reproduction of cells. Then imagine medicine can be attracted by 'Aura', some magnet or electric charge forces, to increase their efficiency.

Title and Abstract

Basic Elements included here are:

Medicine_Particles:

  • small(its proportion to cells as 1 to 10^3);
  • very large amount(10^4)
  • random move from one side towards the other side(like data); disappear at the end(they are consumed)
  • meet empty space: keep move
  • meet other particles:form a group and move together;
  • meet cells:
    • good :move on(enter by zero probability,pe=0%)
    • tumor:enter target by a probability(like pe=10%); lost original velocity(v);stay there;
  • after kill a tumor, change to other inactive particles and move on the the end-side;

Particle_groups:

  • same as single particles only move slower
  • if the group size>= x(like 5), group will stop(v=0) and swallowed by leukocyte

Cells:

  • volume are large, occupy many spaces(30*30, about one tile??)
  • stay still, do not move
  • grow, divide at certain time
    • Good_cells: grows after some time(like t1=10^3)
    • Tumor_cells:grows faster than good cells(like t2⇐500);
      • by a probability(like pt=10%) turns good cells into tumor by a time(like t3>= 200)
      • killed by particles(like n>=10)
      • emit 'Aura'

Aura:

  • small atoms, diffuse around
  • have a short life-time(explode after a short time)
  • attract medicine particle(like fish be eaten by shark)
  • density will be high around tumors(because they die very soon)
  • will do harm to healthy cells(if they live long enough, they will 'eat' healty cell atoms)
  • The life-length and number of Aura reflect how strong it is.

Blood_Streams:

  • Particles will move along blood streams.
  • Empty spaces must be left between Cells.

Big Challenge:

  • Create appropriate Cells is very difficult. Cells must have reasonable shapes, they should not look like square rooms.
  • Cells can grow and divide. They will bump away any particles within that event window.
  • When Cells grow and divide, they will not squeeze out empty spaces. There are always some spaces for Blood streams.
people/xinyu_chen/drugmissile.txt · Last modified: 2014/10/12 21:25 by xychen